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The principal research interest of the lab is to comprehensively understand the biology of specific cancer types that are common in India and distinct from their western counterpart(s). Based on results obtained from two decades of work performed on patient-derived colorectal, pancreatic, esophageal and oral tumor samples, we are presently studying the canonical and aberrant functions of chromatin remodelers ARID1B and ARID2.
In parallel, based on funding from the DBT-Wellcome Trust India Alliance, we are studying early-onset colorectal cancer in the Indian population titled ‘PEACOCC: Pan-India EArly-onset COlorectal Cancer Consortium'. The project involves exome, transcriptome, microbiome profiling of tumor and stool samples followed by validation using cell lines, tumor-derived 3D organoids, nude mice xenografts, and tissue microarrays.
Positions
We are currently seeking potential PhD students with keen interest to apply cutting edge genomics and cell and molecular biology tools in addressing important questions in the field of cancer biology and chromatin remodeling. Students will have freedom to develop the project(s) as per their own interests.
We actively seek applications from highly motivated postdoctoral candidates to work on two broad areas of research:
a) to function as scientific co-ordinator of the DBT Wellcome Trust India Alliance project - 'PEACOCC: Pan India Colorectal Cancer Consortium'.
b) apply state of the art computational and AI approaches to analyze metagenomics data of potential pathogens.
c) to work on tumor exome and RNA Seq data generated in house and elsewhere to study gene fusions, allele specific expression and alternative/novel transcript isoforms.
Details of current projects are given below:
- Studying novel nuclear and cytoplasmic functions of ARID1B.
https://doi.org/10.1242/jcs.251637
- Molecular Characterization of early-onset rectal cancer.
doi: 10.1038/s41388-020-01537-z
- Characterisation of gain of function activity of non-hotspot p53 mutations identified from Indian squamous cell carcinoma patients.
https://doi.org/doi:10.1002/jcp.29332
- Molecular analysis of genetic disorders.
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