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Dr. Murali Bashyam
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Molecular Oncology Group
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Home » Molecular Oncology » Research
Molecular Oncology
Molecular Characterization of early-onset rectal cancer

Colorectal cancer (CRC) is the third most common cancer worldwide and is perhaps the best understood of all cancers. Despite this, our understanding of sporadic early-onset rectal cancer (EORC), the predominant CRC subtype in India, is limited. We have performed the first comprehensive genomic, molecular and clinico-pathological characterization of CRC from India. Surprisingly, a significantly high proportion of EORC do not appear to be driven by either of the two canonical tumorigenesis pathways namely Wnt activation and mismatch repair inactivation, that drive a majority of CRC worldwide. We further identified Ca2+/NFAT signalling as one possible driver of EORC in the absence of Wnt activation. We have now performed next generation sequencing based RNA and exome sequencing of a well characterised set of EORC samples. The results reveal ARID2, a component of the SWI/SNF chromatin remodelling complex, to be a novel tumor suppressor in EORC.


Enrichment of 30 COSMIC signatures in EOSRC-IN (Indian CRC cohort) with respect to TCGA CRC cohorts.
People involved

Dr Asmita Gupta
Research Associate I


Ms Sanjana Sarkar
Junior Research Fellow

Ms Shivani Yadav
Data Analyst

Ms K Padmavathi
Project-Senior Research Fellow
Funding Agencies : NIH, DBT, DST
Contact Information
Email: bashyam<at>cdfd.org.in

Phone: +91-40-24749383
Fax: +91-40-24749448
Last updated on : Tuesday, 2nd March, 2021.

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