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Dr. Murali Bashyam
Research Interests
Molecular Oncology Group
Past Members
Awards, Fellowships and Honours
Home » Molecular Oncology » Research
Molecular Oncology
Molecular Characterization of early-onset rectal cancer

Colorectal cancer (CRC) is the third most common cancer worldwide and is perhaps the best understood of all cancers. Although rapid advances have been made in patient management and therapy for most forms of CRC, our understanding of sporadic early-onset rectal cancer (EORC), the predominant CRC subtype in India, is limited. We have performed the first comprehensive molecular and clinico-pathological characterization of CRC from India. Surprisingly, a significantly high proportion of EORC do not appear to be driven by either of the two canonical tumorigenesis pathways namely Wnt activation and mismatch repair inactivation that drive a majority of CRC worldwide. In addition, EORC also exhibits unique features with respect to chromosomal instability and KRAS mutation status. Efforts are currently underway, using next generation RNA and exome sequencing, to understand the biology of this unique CRC subtype. In parallel, our comprehensive studies on the familial cancer syndrome Hereditary Non-Polyposis Colorectal Cancer has revealed involvement of novel genetic lesions among Indian patients.

Fig.1. Identification of differential copy number alterations in Wnt- microsatellite stable early-onset rectal cancer (RC). aCGH carried out on genomic DNA isolated from early-onset RC samples reveal a recurrent amplification at 17q12 harboring ERBB2 and GRB7 oncogenes.
People involved

Pratyusha Bala
Senior Research Fellow
Full scholarship and travel award from the SciGenome Research Foundation for NGBT-2016.

Ashmala Naz
Senior Research Fellow

Dr Asmita Gupta

Indra Sara Lama
Senior Technical Assistant
Funding Agencies : NIH, DBT, DST
Contact Information
Email: bashyam<at>cdfd.org.in

Phone: +91-40-24749383
Fax: +91-40-24749448
Last updated on : Thursday, 16th August, 2018.

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