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Dr. Maddika Subba Reddy
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Home » Cell Death & Cell Survival » Publications
Cell Death & Cell Survival
  1. Shinde SR, Maddika S. PTEN regulates glucose transporter recycling by impairing SNX27 retromer assembly. Cell Reports . 2017 (In press).

  2. Gangula NR, Maddika S. Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1. J Biol Chem. 2017; 292(34): 13947-13958.

  3. Kumar P, Munnangi P, Chowdary KR, Shah VJ, Shinde SR, Kolli NR, Halehalli RR, Nagarajaram HA, Maddika S. A human tyrosine phosphatase interactome mapped by proteomic profiling. J Proteome Res. 2017; 16(8): 2789-2801.

  4. Joshi K, Shah VJ, Maddika S. GINS complex protein Sld5 recruits SIK1 to activate MCM helicase during DNA replication. Cell Signal. 2016; 28(12): 1852-1862.

  5. Shinde SR, Maddika S. PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7. Nature Communications.2016; 7: 10689.

  6. Raychaudhuri K, Chaudhary N, Gurjar M, D'Souza R, Limzerwala J, Maddika S, Dalal SN. 14-3-3σ Gene Loss Leads to Activation of the Epithelial to Mesenchymal Transition Due to the Stabilization of c-Jun Protein. J Biol Chem. 2016; 291(31): 16068-81.

  7. Palicharla VR, Maddika S.HACE1 mediated K27 ubiquitin linkage leads to YB-1 protein secretion. Cell Signal. 2015; 27(12): 2355-62.

  8. Kapoor R, Arora S, Ponia SS, Kumar B, Maddika S, Banerjea AC. The miRNA miR-34a enhances HIV-1 replication by targeting PNUTS/PPP1R10, which negatively regulates HIV-1 transcriptional complex formation. Biochem J. 2015; 470(3): 293-302.

  9. Jangamreddy JR, Panigrahi S, Lotfi K, Yadav M, Maddika S, Tripathi AK, Sanyal S, Łos MJ. Mapping of apoptin-interaction with BCR-ABL1, and development of apoptin-based targeted therapy. Oncotarget. 2014; 5(16): 7198-211.

  10. Chaudhary N, Maddika S. WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels. Mol Cell Biol. 2014; 34(19): 3754-64.

  11. Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitylation and stabilization of PTEN by USP13. Nature Cell Biol. . 2013; 15(12): 1486-1494.

  12. Gangula NR, Maddika S. WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). J Biol Chem. 2013; 288 (48): 34545-54.

  13. Kavela S., Shinde SR., Ratheesh R., Viswakalyan K., Bashyam MD., Swarnalata G., Vamsy G., Pattnaik S., Rao S., Sastry RA., Srinivasulu M., Chen J & Maddika S.PNUTS functions as a proto-oncogene by negatively regulating PTEN. Cancer Research. 2013; 73(1): 205-14.

  14. Shinde SR, Gangula NR, Kavela S, Pandey V, Maddika STOPK and PTEN participate in CHFR mediated mitotic checkpoint. Cell Signal. 2013; 25(12): 2511-7.

  15. Kuna RS, Girada SB, Asalla S, Vallentyne J, Maddika S Patterson JT, Smiley DL, DiMarchi RD, Mitra P. Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells. Am J Physiol Endocrinol Metab.2013; 305(2): E161-70.

  16. Maddika S., Kavela S., Rani M., Palicherla PV and Chen J. WWP2 is an E3 ubiquitin ligase for PTEN. Nature Cell Biol. 2011; 13(6): 728-33.

  17. Maddika S., Sy SM and Chen J. Functional interaction between Chfr and Kif22 controls genomic stability. J Biol Chem. 2009; 284(19):12998-3003.

  18. Maddika S and Chen J. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3-ligase. Nature Cell Biol 2009; 11(4):409-19.

  19. Maddika S., Panigrahi S., Weichec E., Wesselborg S., Fischer U., Schulze-Osthoff K and Los M. Unscheduled Akt- triggered activation of CDK2 as a key effector mechanism of apoptin’s anti-cancer toxicity. Mol Cell Biol. 2009; 29(5): 1235-48.

  20. Ghavami S, Eshraghi M, Kadkhoda K, Mutawe MM, Maddika S, Bay GH, Wesselborg S, Halayko AJ, Klonisch T and Los M. Role of BNIP3 in TNF-induced cell death--TNF upregulates BNIP3 expression. Biochim Biophys Acta. Mol Cell Research 2009; 1793(3):546-60.

  21. Maddika S., Ande SR., Weichec E., Hansen LL., Wesselborg S and Los M. Akt mediated CDK2 phosphorylation regulates its dual role in cell cycle and apoptosis. Journal of Cell Sci. 2008, 121 (7): 979-88.

  22. Maddika S., Weichec E., Ande SR., Poon IK., Fischer U., Wesselborg S., Jans DA., Schulze-Osthoff K and Los M. Interaction with PI3-Kinase contribute to the cytotoxic activity of apoptin. Oncogene 2008, 27 (21): 3060-5.

  23. Maddika S., Bay GH., Kroczak TZ., Ande SR., Maddika S., Weichec E., Gibson SB and Los M. Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin induced cell death. Cell Proliferation 2007, 40 (6): 435-48.

  24. Burek M#., Maddika S#., Burek CJ., Daniel PT., Schulze-Osthoff K., and Los M. Apoptin induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent. Oncogene 2006. 25(15): 2213-22. [# Equal First Authorship]

  25. Maddika S., Booy EP., Johar D., Gibson SB., Ghavami S., and Los M. Tumor-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell death mediators by a Nur77 dependent pathway. Journal of Cell Sci. 2005, 118 (19): 4485 – 4493.

  26. Hashemi M., Karami-Tehrani F., Ghavami S., Maddika S., and Los M. Adenosine and Deoxyadenosine induces apoptosis in the estrogen receptor positive and negative human breast cancer cells via the intrinsic pathway. Cell proliferation 2005, 38 (5): 269-85.

  27. Barczyk K., Kreuter M., Pryjma J., Booy EP., Maddika S., Ghavami S., Berdel WE., Roth J., and Los M. Serum cytochrome c indicates invivo apoptosis and can serve as a prognostic marker during cancer therapy. Int J Cancer 2005; 116(2); 167-73.

  1. Kumar P, Maddika S.Cellular dynamics controlled by phosphatases. J Indian Inst Sci. 2017; 97: 129-145.

  2. Shinde SR, Maddika S. Post translational modifications of Rab GTPases. Small GTPases. 2017:1-8.

  3. Shinde SR, Maddika S. A modification switch on a molecular switch: Phosphoregulation of Rab7 during endosome maturation. Small GTPases. 2016; 7(3): 164-7.

  4. Jain MV, Paczulla AM, Klonisch T, Dimgba FN, Rao SB, Roberg K, Schweizer F, Lengerke C, Davoodpour P, Palicharla VR, Maddika S, Łos M. Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J Cell Mol Med. 2013; 17(1): 12-29.

  5. Ande SR, Chen J, Maddika S E3 ubiquitin ligases as drug targets for cancer therapies. Eur J Pharmacol. 2009, Invited review.

  6. Los M., Maddika S and Schulze-Osthoff K. Switching Akt: From survival signaling to deadly response. BioEssays 2009; 31(5):492-5.

  7. Maddika S., Ande SR., Panigrahi S., Paranjothy T., Weglarczyk K., Zuse A., Eshraghi M., Manda KD., Wiechec E and Los M. Cell survival, cell death and cell cycle pathways are interconnected. Drug Resist Updates 2007, 10 (1-2) 13-29.

  8. Kroczak TJ., Baran J., Pryjma J., Siedlar M., Reshedi I., Hernandez E., Alberti E., Maddika S., and Los M. The emerging importance of DNA mapping and other genome based techniques as tools to identify new drug targets and as a mean of therapy personalization. Expert Opin. Ther. Targets 2006: Vol 10(2): 289-302.

  9. Maddika S., Mendoza FJ., Hauff K., Zamzow CR., Paranjothy T and Los M. Cancer Selective Therapy of the Future: Apoptin and Its Mechanism of Action. Cancer Biol Ther. 2006 Vol 5(1): 10-19.

  10. Pour-Jafari H, Ghavami S, and Maddika S. Mitochondrial physiology and toxicity (mitotoxicity); importance for the immune system, programmed cell death and cancer. Curr. Med. Chem. AIAA 2005 Vol 4 (4); 439-48.

  11. Kreuter M., Langer C. Kerkhoff C., Reddanna P., Kania A.L., Maddika S., Chlichlia K., Bui NT., and Los M (2004) Stroke, myocardial infarct, acute and chronic inflammatory diseases: Caspases and other apoptotic molecules as targets for drug development. Arch. Immunol. Ther. Exp. 2004,Vol 52, 141-155.

List of book chapters:
  1. Ghavami S., Barczyk K., Maddika S., Pourjafari H., Kroczak T., and Los, M. Monitoring of programmed cell death in vivo: new methods of cancer therapy monitoring. In: Apoptotic pathways as target for novel therapies in cancer and other diseases. Edited by M. Los & S.B Gibson; Kluwer Academic Press, (2004), ISBN 0-387-23384-9.

  2. Banerji S., Ande SR., Maddika S., Banerji V., Rashedi I., Owens NW., Zuse A., Schweizer F. and Los M.“Peptides and peptidomimetics as cancer therapy sensitizing agents” in: Sensitization of Cancer Cells
Contact Information
Email: msreddy<at>cdfd.org.in
Phone: +91-40-27216168
Fax: +91-40- 27216006
Last updated on: Tuesday, 7th November, 2017.

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