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Dr.Sangita Mukhopadhyay
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Home » Molecular Cell Biology » Publications
Molecular Cell Biology
  1. N. R. Rameshwaram, P.Singh, S. Ghosh and S. Mukhopadhyay (2018). Lipids and lipases in the physiology and pathogenicity of Mycobacterium tuberculosis and other intracellular bacteria. Future Microbiology Microbiology – In Press.

  2. P. Singh, N. R. Rameshwaram, S. Ghosh and S. Mukhopadhyay (2018). Cell envelope lipids in the pathophysiology of Mycobacterium tuberculosis. Future Microbiology 13: 689-710.

  3. G. Pradhan, R. Shrivastva, and S. Mukhopadhyay (2018). Mycobacterial PknG Targets the Rab7l1 Signaling Pathway To Inhibit Phagosome–Lysosome Fusion. Journal of Immunology 201(5):1421-1433.

  4. A. Ahmed, K. Dolasia and S. Mukhopadhyay (2018). Mycobacterium tuberculosis PPE18 Protein Reduces Inflammation and Increases Survival in Animal Model of Sepsis. Journal of Immunology. April 18, 2018, doi:10.4049/jimmunol.1602065.

  5. K. Dolasia, M. K. Bisht, G. Pradhan, A. Udgata & S. Mukhopadhyay (2017). TLRs/NLRs: Shaping the landscape of host immunity. International Reviews of Immunology. doi:10.1080/08830185.2017. 1397656.

  6. P.R. Abraham, N. Pathak, G. Pradhan , G. Sumanlatha and S. Mukhopadhyay (2017). The N-terminal domain of Mycobacterium tuberculosis PPE17 (Rv1168c) protein plays a dominant role in inducing antibody responses in active TB patients. PLoS One 26: e0179965.

  7. S. Mukhopadhyay and S. Ghosh (2017). Mycobacterium tuberculosis: what is the role of PPE2 during infection? Future Microbiology 12: 457-460. doi: 10.2217 (Invited Editorial Article).

  8. K.H. Bhat , S. Srivastava , S.K. Kotturu , S. Ghosh and S. Mukhopadhyay (2017). The PPE2 protein of Mycobacterium tuberculosis translocates to host nucleus and inhibits nitric oxide production. Scientific Reports7:39706.

  9. R. N. Rao, R. Shrivastava, G. Pradhan, P. Singh and S. Mukhopadhyay (2017). Phagosome lysosome Fusion Hijack - An Art of Intracellular Pathogens. Proceedings of the Indian Academy of Science doi: 10.16943/ptinsa/2017/48971

  10. A. Udgata, R. Qureshi and S. Mukhopadhyay (2016). Transduction of functionally contrasting signals by two mycobacterial PPE proteins downstream of TLR2 receptors. Journal of Immunology 197(5):1776-1787.

  11. Parul Singh, Rameshwaram Nagender Rao, Jala Ram Chandra Reddy, RBN Prasad, Sandeep Kumar Kotturu, Sudip Ghosh & Sangita Mukhopadhyay (2016). PE11, a PE/PPE family proteinof Mycobacterium tuberculosis is involved in cell wall remodeling and virulence. Scientific Reports, 6:21624. doi: 10.1038/srep21624.

  12. P. R. Abraham, A. Udgata, G. S. Latha, and S. Mukhopadhyay (2016). The Mycobacterium tuberculosis PPE protein Rv1168c induces stronger B cell response than Rv0256c in active TB patients. Infection Genetics and Evolution, 40:339-345

  13. A. Ahmed, A. Das and S. Mukhopadhyay (2015). Immunoregulatory functions and expression patterns of PE/PPE family members: Roles in pathogenicity and impact on anti-tuberculosis vaccine and drug design. IUBMB Life 67:414-427.

  14. K. Hussain Bhat and S. Mukhopadhyay (2015). Macrophage takeover and the host-bacilli interplay during tuberculosis. Future Microbiol. 10: 853-872.

  15. G. Sreejit, A. Ahmed, N. Parveen, V. Jha, V. L.Valluri, S. Ghosh and S. Mukhopadhyay (2014). The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (.2M) affecting antigen presentation function of macrophage. PLoS Pathogens 10:e1004446.

  16. P. R. Abraham, G. S. Latha, V. L. Valluri and S. Mukhopadhyay (2014). Mycobacterium tuberculosis PPE protein Rv0256c induces strong B cell response in tuberculosis patients. Infection Genetics and Evolution 22:244-249.

  17. K. H. Bhat, A. Das, A. Srikantam and S. Mukhopadhyay (2013) PPE2 protein of Mycobacterium tuberculosis inhibits production of nitric oxide in activated macrophages. Annals of the New York Academy of Sciences 1283:97-101.

  18. N. Parveen, R. Varman, S. Nair, G. Das, S Ghosh and S. Mukhopadhyay (2013). Endocytosis of Mycobacterium tuberculosis heat shock protein 60 is required to induce interleukin-10 production in macrophages. Journal of Biological Chemistry 288:24956-24971.

  19. K. H. Bhat, A. Ahmed, S. Kumar, P. Sharma and S. Mukhopadhyay (2012). Role of PPE18 protein in intracellular survival and pathogenicity of Mycobacterium tuberculosis in mice. PLoS ONE 7:e52601.

  20. Y. Akhter, M. T. Ehebauer, S. Mukhopadhyay , and S. E. Hasnain (2012). The PE/PPE multigene family codes for virulence factors and is a possible source of mycobacterial antigenic variation: perhaps more? Biochimie 94:110-116.

  21. K. H. Bhat, C. K. Chaytanya, N. Parveen, R. Varman, S. Ghosh and S. Mukhopadhyay (2012). The PPE protein Rv1168c of Mycobacterium tuberculosis augments transcription from HIV-1 LTR promoter. Journal of Biological Chemistry 287:16930-16946.

  22. S. Mukhopadhyay, S. Nair and S. Ghosh (2011). Pathogenesis in tuberculosis: transcriptomic approaches to unraveling virulence mechanisms and finding new drug targets. FEMS Microbiology Reviews 36:463-485.

  23. S. Mukhopadhyay and K. N. Balaji (2011). The PE and PPE proteins of Mycobacterium tuberculosis. Tuberculosis 91:441-447.

  24. A. Das and S. Mukhopadhyay (2011). The evil axis of obesity, inflammation and type-2 diabetes. Endocrine, Metabolic & Immune Disorders - Drug Targets 11:23-31.

  25. S. Nair, A. D. Pandey and S. Mukhopadhyay (2011). The PPE18 protein of Mycobacterium tuberculosis inhibits NF-kB/rel-mediated proinflammatory cytokine production by upregulating and phosphorylating SOCS3 protein. Journal of Immunology 186:5413-5424.

  26. K. Alam, S. Ghousunnissa, S. Nair, V. L. Valluri, and S. Mukhopadhyay (2010). Glutathione-redox balance regulates c-rel-driven IL-12 production in macrophages: possible implications in antituberculosis immunotherapy. Journal of Immunology 184:2918-2929.

  27. S. Nair, P. A. Ramaswamy, S. Ghosh, D. C. Joshi, N. Pathak, I. Siddiqui, P. Sharma, S. E. Hasnain, S. C. Mande, and S. Mukhopadhyay (2009). The PPE18 of Mycobacterium tuberculosis interacts with TLR2 and activates IL-10 induction in macrophage. Journal of Immunology 183:6269-6281.

  28. N. Bashir, F. Kounsar, S. Mukhopadhyay, and S. E. Hasnain (2010). Mycobacterium tuberculosis conserved hypothetical protein rRv2626c modulates macrophage effector functions. Immunology 130:34-45.

  29. M. A. Hussain, S. A. Naveed, L. A. Sechi, S. Ranjan, A. Alvi, I. Ahmed, A. Ranjan, S. Mukhopadhyay, and N. Ahmed (2008). Isocitrate dehydrogenase of Helicobacter pylori potentially induces humoral immune response in subjects with peptic ulcer disease and gastritis. PLoS ONE 3:e1481.

  30. S. Tundup, N. Pathak, M. Ramanadham, S. Mukhopadhyay, K. J. Murthy, N. Z. Ehtesham, and S. E. Hasnain (2008). The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS ONE 3:e3586.

  31. N. Khan, K. Alam, S. Nair, V. L. Valluri, K.J. R. Murthy and S. Mukhopadhyay* (2008). Strong immune responses to the PPE protein Rv1168c are associated with active tuberculosis disease. Clinical and Vaccine Immunology 15:974-980.

  32. N. Khan, K. Alam, S. C. Mande, V. L. Valluri, S. E. Hasnain and S. Mukhopadhyay (2008). Mycobacterium tuberculosis heat shock protein 60 modulates immune response to PPD by manipulating the surface expression of TLR2 on macrophages. Cellular Microbiology 10:1711-1722.

  33. N. Khan, S. Ghousunnissa, S. M. Jegadeeswaran, D. Thiagarajan, S. E. Hasnain, and S. Mukhopadhyay* (2007). Anti-B7-1/B7-2 antibody elicits innate-effector responses in macrophages through NF-kB-dependent pathway. International Immunology 19:477-486.

  34. S. Mukhopadhyay, S. Nair, and S. E. Hasnain (2007) Nitric oxide: Friendly rivalry in tuberculosis. Current Signal Transduction Therapy 2:121-128.

  35. C. S. Boddupalli, S. Ghosh, S. S. Rahim, S. Nair, N. Z. Ehtesham, S. E.. Hasnain and S. Mukhopadhyay (2007). Nitric oxide inhibits interleukin-12 p40 through p38 MAPK-mediated regulation of calmodulin and c-rel. Free Radical Biology and Medicine 42:686-697.

  36. N. Khan, S. S. Rahim, C. S. Boddupalli, S. Ghousunnissa, S. Padma, N. Pathak, D. Thiagarajan, S. E. Hasnain and S. Mukhopadhyay* (2006). Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein. Blood 107:1513-1520.

  37. S. S. Rahim, N. Khan, C. S. Boddupalli, S. E. Hasnain and S. Mukhopadhyay (2004). IL-10 mediated suppression of IL-12 production in RAW 264.7 cells also involves c-rel transcription factor. Immunology 114:313-321.

  38. N. Silswal, A. K. Singh, B. Aruna, S. Mukhupadhyay, S. Ghosh, and Z. Ehtesham (2005). Human resistin stimulates the pro-inammatory cytokines TNF-a and IL-12 in macrophages by NF-.B-dependent pathway. Biochemical and Biophysical Research 334:1092-1101.

  39. S. Ghosh, S. Rasheedi, S. S. Rahim, S. Banerjee, R. K. Choudhary, P. Chakhaiyar, N. Z. Ehtesham, S. Mukhopadhyay and S. E. Hasnain (2004). Method for enhancing solubility of the expressed recombinant proteins in Escherichia coli. Biotechniques 37:418-423.

  40. S. Mukhopadhyay, V. M. L. Srivastava, P. K. Murthy and S. E. Hasnain (2004). Poorer NF-kB signaling by microfilariae in macrophages from BALB/c mice affects their ability to produce cytotoxic levels of nitric oxide to kill microfilariae. FEBS Letters 567:275-280.

  41. R. K. Choudhary, S. Mukhopadhyay, P. Chakhaiyar, N. Sharma, K. J. R. Murthy, V. M. Katoch and S. E. Hasnain (2003). PPE antigen Rv2430c of Mycobacterium tuberculosis induces a strong B cell response. Infection Immunity 71:6338-6343.

  42. M. D. Bashyam and S. Mukhopadhyay (2003). Status of Tuberculosis in India-2003 (R. Nayak, M. S. Shaila and G. R. Rao eds.) and Trends in Malaria and Vaccine Research: The current Indian Scenario (D. Raghunath and R.Nayak eds.). Book Review, Infection, Genetics and Evolution 3:75-77.

  43. Ghosh, S., Singh, A. K., Aruna, B., S. Mukhopadhyay, and Ehtesham, N. Z. (2003). The genomic organization of mouse resistin reveals major difference from the human resistin. Gene 305:27-34.

  44. S. Bhatia, S. Mukhopadhyay, E. Jarman, G.Hall, A. George, S. Rath, J. R. Lamb, and V. Bal, (2002). Scavenger receptor-specific allergen delivery elicits IFN-g-dominated immunity and directs established Th2-dominated responses to a non-allergic phenotype. Journal of Allergy and Clinical Immunology 109:321-328.

  45. S. Mukhopadhyay, M. Mohanty, A. Mangla, A. George, V. Bal, S. Rath, and B. Ravindran (2002). Macrophage effector functions controlled by Bruton's tyrosine kinase are more crucial for microfilarial clearance than the cytokine balance of T cell responses. Journal of Immunology 168: 2914-2921.

  46. B. Ravindran, P. K. Sahoo, M. Mohanty, S. Mukhopadhyay and A. P. Dash (1999). Increased susceptibility of mice with XID mutation to Brugia malayi infection. Medical Science Research, 27:135-137.

  47. S. Mukhopadhyay, P. K. Sahoo, A. George, V. Bal, S. Rath and B. Ravindran (1999) Delayed clearance of filarial infection and enhanced Th1 immunity due to modulation of macrophage APC functions in xid mice. Journal of Immunology 163:875-883.

  48. S. Mukhopadhyay, A. George, V. Bal, B. Ravindran and S. Rath (1999). Bruton's tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of interleukin-12 induction. Journal of Immunology 163:1786-1792.

  49. S. Mukhopadhyay, A. P. Dash & B. Ravindran (1996) Setaria digitata in Mastomys coucha: An animal model for chemotherapeutic and immunobiological studies. Parasitology 113:323-330.

  50. S. Mukhopadhyay & B. Ravindran (1997) Antibodies to diethylcarbamazine potentiate the anti-filarial Immunology activity of the drug. Parasite 19:191-195.

List of Patents

  1. S. Mukhopadhyay*, K. H. Bhat and N. Khan. A novel protein as potential candidate for development of anti-tuberculosis therapeutics.

    US Patent Application Number: 12/551,115;
    Invention ID: IN-000044-02-US-REG
    Patent No: US-8603739B2
    Date of grant: December 10, 2013

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Last updated on: Thursday, 20th September, 2018.

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