Online Talk

My research focuses on dissecting how centrosomes and cilia function as molecular switches in determining homeostatic control of neural stem cells. We have identified centrosomes and cilia biogenesis principles during the last decade, applying Drosophila genetics and biochemistry. We now wish to understand how are these structures critically regulating neural stem cells' functions in human brain development and degeneration. To this end, we are pioneered to generate self-assembling 3D human brain organoids. My laboratory is now determined to decipher cilia's general rules as a molecular switch in brain development, cell physiology, neurodegeneration, and tumorigenesis, with a particular emphasis on translating basic research into the identification of molecular targets of human diseases. prophylactic therapeutics for disease prevention.