Microbial process for arginine production

(Inventors: J. Gowrishankar et al.) 

Brief description:  

The invention exploits the novel identification of mutations in a regulator gene argP of E. coli that render constitutive the expression of an arginine exporter ArgO. Accordingly, the invention describes processes for increased production of arginine by fermentation, with the use of E. coli strains carrying mutations in argR (that derepress arginine biosynthesis) in combination with mutations in argP (that lead to increased arginine export into the culture medium).  

Utility: Arginine is an essential amino acid that is used as a nutrient supplement for parenteral hyperalimentation in clinical practice as well as in stockfeeds for animals, poultry, etc. 

Research publications: 

Nandineni, M.R., and Gowrishankar, J. 2004. Evidence for an arginine exporter encoded by yggA (argO) that is
           regulated by the LysR-type transcriptional regulator ArgP in Escherichia coli. J. Bact. 186: 3539-3546. [PDF] 

Patents filed: 

[PCT]     [US]    [Japan]      

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