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Home » Dr.T.Ramasarma
Distinguished Chair, CDFD 
Ph.D. from University of Bombay.
Honorary Scientist, Indian National Science Academy

T. Ramasarma obtained the bachelor degree in Chemistry from Andhra University (1951), post-graduation in Chemical Engineering from the Indian Institute of Science (IISc) (1953) and Ph. D from Bombay University in Biochemistry (1956). Dr. Ramasarma did post-doctoral work at the National Research Council, Saskatoon, Canada (1956-57), and at the Enzyme Institute, University of Wisconsin, Madison, U.S.A. (1957-58). He returned to India and started research career at IISc and had been a faculty member there till his retirement in 1992. He became a Professor in 1972, the Dean of science faculty (1982-84), and the Chairman of the Department of Biochemistry (1986-89). He worked there as CSIR Emeritus Scientist (1992-97) and as INSA Senior Scientist (1997-2002), and continues association with Solid State & Structural Chemistry Unit, IISc as INSA Honorary Scientist. Dr. Ramasarma joined CDFD as a Distinguished Chair in 2004.

In his long distinguished career Dr. Ramasarma had been honoured as a visiting scientist in leading universities and institutes worldwide: Albert Einstein College of Medicine, New York, U.S.A. (1965-66, 1970), St. Louis University School of Medicine, St. Louis, U.S.A.(1966-67), University of Liverpool, U.K. 1971), University of Wisconsin, Madison as Brittingham Visiting Professor (1980), University of Southern California, Los Angeles, U.S.A. (1983), and University of Hyderabad as Jawaharlal Nehru Professor (1995).

Dr. Ramasarma's research during the past five decades contributed significantly to the contemporary progress in the area of biological oxidations. He published over 250 papers in a variety of national and international journals.


List of Latest Publications

  • Aparna V. S. Rao, H. N. Ravishankar and T. Ramasarma Diperoxovanadate participates in peroxidation reactions of H2O2 in presence of abundant catalase. Biochim. Biophys. Acta 1381, 249-255 (1998).

  • T. Ramasarma A profile of adenosine triphosphate Curr. Sci. 74, 953-966 (1998).

  • T. Ramasarma Adaptation of cellular thermogenic reactions Advances in Organ Biology, ed. E.E.Bittar and D.K.Das, (Jai Press, Stamford, CN, U.S.A.) 6, 219-239 (1998).

  • V. Natarajan, S. Vepa, R. Shamlal, M. Al-Hassani, T. Ramasarma, H.N. Ravishank ar and W. H. Scribner Tyrosine kinases and calcium-dependent activation of endothelial cell phospholipase D by diperoxovanadate Mol. Cell. Biochem. 183, 113-124 (1998).

  • T. Ramasarma Endogenous inhibitors of cholesterol biosynthesis Indian J. Physiol. Allied Sci. (1997-Golden Jubilee issue) pp 38-47 (1998).

  • T. Ramasarma Nitric oxide, the gas in the news Resonance 4, 31-41(1999)

  • T. Ramasarma and B. V. Venkataraman A perspective of smooth muscle contractility through actions of vanadium compounds Indian J. Physiol. Pharmacol. 43, 277-295 (1999)

  • Aparna V. S. Rao, P. D. Sima, J. R. Kanofsky and T. Ramasarma Inactivation of glucose oxidase by diperoxovanadate-derived oxidants Arch. Biochem. Biophys. 369, 163-173 (1999)

  • T. Ramasarma Is it fair to describe a protein recruited for many cellular chores as moonlighting and promiscuous? Curr. Sci. 77, 202-205 (1999)

  • T. Ramasarma A perspective of biological supramolecular electron transfer Indian J. Biochem. Biophys. 36, 379-397 (1999)

  • H.N. Ravishankar, Sekhar S. Boddupalli, A.S. Gaikwad and T. Ramasarma Survival of rats under cold stress depends on dietary fat Environ. Nutr. Interactions 3, 257-265 (1999)

  • Aparna V.S. Rao and T. Ramasarma NADH-dependent decavanadate reductase, an alternative activity of NADPH-specific isocitrate dehydrogenase Biochim. Biophys. Acta 1474, 321-330 (2000)

  • T. Ramasarma Some radical queries Toxicology 148, 85-91 (2000)

  • T. Ramasarma In praise of the hydrogen bond in "Supramolecular and Colloidal Structures in Biomaterials and Biosubstrates" (2000) ed. M. Lal, P. J. Lillford, V. M. Naik and V. Prakash, (Imperial College Press and the Royal Society, London, U.K.) pp. 450-462

  • B. G. Maiya and T. Ramasarma DNA, a molecular wire or not - The debate continues Curr. Sci. 80,1523-1530 (2001)

  • T. Ramasarma and C. Ramakrishnan On the importance of backbone loop and peptide flip in the Walker sequence in F1-ATPase action Indian J. Biochem. Biophys. 39, 5-15 (2002)

  • C. Ramakrishnan, V. S. Dani and T. Ramasarma A conformational analysis of Walker loop motif A [GXXXXGKT] in nucleotide-binding and other proteins Protein Engineering 15, 783-793 (2002)

  • N.I. Islam, S. Sarmah, P. Hazarika, Aparna V.S. Rao and T. Ramasarma Peroxo-bridged divanadates as selective bromide oxidants in bromoperoxidation Mol. Cell. Biochem 236, 95-105 (2002)

  • R. Bindu, B.V. Venkataraman, Aparna V.S. Rao and T. Ramasarma Relaxation of arterial smooth muscle by water-soluble derivatives of coenzyme Q (ubiquinone) Indian J. Biochem. Biophys. 40, 1-15 (2003)

  • T. Ramasarma The Beginning of Biochemistry Resonance 8, 27-32 (2003)

  • Transmembrane domains T. Ramasarma and N. V. Joshi Encyclopedia of the Human Genome, Nature Publishing Group, vol 5, pp 606-613 (2003)

  • T. Ramasarma The emerging redox profile of vanadium Proc. Indian natn. Acad. Sci. B69, 649-672 (2003)

  • T.P.A. Devasagayam, K.K. Boolor and T. Ramasarma Methods of estimating lipid peroxidation: An analysis of merits and demerits Indian J. Biochem. Biophys. 40, 300-308 (2003)

  • B.V. Venkataraman and T. Ramasarma Cardiovascular effects of vanadium In: Antioxidants and cardiovascular diseases, ed. R. Nath, M. Khuller and P.K. Singal, Narosa Publ. New Delhi, 2003, pp 211-223

  • R. Bindu, B.V. Venkataraman, Aparna V.S. Rao and T. Ramasarma Relaxation of arterial smooth muscle: a new function of water-soluble degradation product of coenzyme Q (ubiquinone) BioFactors, 18, 137-143 (2003)

  • T. Ramasarma and H. N. Ravishankar Formation of an oxo-radical of peroxovanadate during reduction of diperoxovanadate with vanadyl sulfate or ferrous sulfate Biochemica Biophysica Acta (2004) (In press).

  • T. Ramasarma A view on how a protein gains catalysis In: Proc. 7th Intl. Symposium of Protein Structure-Function Relationship, Karachi, Pakistan, ed. Atiya Abbassi, (In press) (2003)

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    Publications in Press

  • Lipid quinones, Advances in Lipid Research, Academic Press, NY, 6, 107-180 (1968).

  • Control of biogenesis of isoprenoid compounds in animals, Current Topics in Cell ular Regulation, Academic Press, NY, 6, 169-207 (1972).

  • Bioscience education in developing countries, editors: T. Ramasarma, P.N. Avadha ni & S. Radhakrishna, COSTED, Madras (1978).

  • Basics in bioenergetics, C.K.R. Kurup & T. Ramasarma,. COSTED, Madras (1979).

  • Does vanadium play a role in cellular regulation? T. Ramasarma & F. L. Crane, C urrent Topics in Cellular Regulation, Academic Press, NY, 20, 247-301 (1981).

  • Generation of H2O2 in biomembranes, T. Ramasarma, Biochimica Biophysica Acta, El sevier publishers, 694, 69-73 (1982).

  • Natural occurrence and distribution of coenzyme Q and Metabolism of coenzyme Q, Two chapters in the book on Coenzyme Q, editor, G. Lenaz, Wiley Press (1984) pp 67-81; 131-142.

  • Trends in bioenergetics and biotechnological processes, editors: G.S. Singhal & T. Ramasarma, Today & Tomorrow's Printers and Publishers, New Delhi (1991).

  • Some excitements during four decades of biochemical research, T. Ramasarma, in " History of Development of Biochemistry and Molecular Biology in India" (1996), editor: D. P. Burma, (Indian National Science Academy, New Delhi) pp. 53 - 66.

  • Adaptation of cellular thermogenic reactions, T. Ramasarma, Advances in Organ Bi ology, editors: E.E.Bittar and D.K.Das, (Jai Press, Stamford, CN, (U.S.A.) 6, 21 9-239 (1998)

  • In praise of the hydrogen bond, T. Ramasarma in "Supramolecular and Colloidal St ructures in Biomaterials and Biosubstrates" (2000) ed. M. Lal, P. J. Lillford, V . M. Naik and V. Prakash, (Imperial College Press and the Royal Society, London, U.K.) pp. 450-462.

  • Transmembrane domains, T. Ramasarma and N. V. Joshi, Encyclopedia of the Human Genome, Nature Publishing Group, vol 5, 606-613 (2003).
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    Awards & Recognitionss

    • Sarma Memorial Award, Society of Biological Chemists (India) (1977)
    • Silver Jubilee Award for Scientific Research, Mysore University (1980)
    • Damodaran Memorial Lecture, Kerala University (1988)
    • Fellow, Indian National Science Academy (1988)
    • Life Sciences Award, Federation of Indian Chamber of Commerce and Industry (1988)
    • Prof. S.S. Koppalikar Memorial Endowment Lecture, Kumta, Karnataka (1994)
    • Yellapragada SubbaRow Memorial Oration, Sri Venkateswara Institute of Medical Sciences, Tirupati (1995)
    • Motlag Endowment Lectures, University of Madras (1997)
    • Distinguished Career Award, South Asian Society on Atherosclerosis and Thrombosis, Mumbai (2000)


    Scientific Contribution & Achievements

    Research career spanning over the past 5 decades has contributed significantly to the contemporary progress in the area of biological oxidations. Some of his recent findings include the following :
    Recent Findings

    1. New functions of coenzyme Q: Water-soluble derivative of the lipid-quinone, coenzyme Q with side chain truncated by oxidation promoted relaxation of contracted arterial smooth muscle, much like nitric oxide. This opens potential of soluble forms of Q for alternate function besides well-known electron transport in mitochondria.

    2. Cellular thermogenesis: An scheme involving activation of alpha-adrenergic receptor, generation of hydrogen peroxide, release of iron from stores and activation of NADPH-consuming lipid peroxidation is proposed as a heat-producing mechanism. By not involving any effect on ATP synthesis it has advantage over the mechanism dependent on uncoupling protein and proton discharge in mitochondria.

    3. Hydrogen peroxide in cellular functions: Regulation of cellular metabolism by oxidative modifications by hydrogen peroxide had been supported by finding of rapid inactivation of several enzymes such as HMG-CoA reductase, glucose oxidase and glyceraldehydes3-phosphate dehydrogenase. Hydrogen peroxide, occurring in small concentrations, seems to act in presence of abundant cellular peroxicidal enzymes such as catalase, by forming a diperoxo-complex with vanadium that is stable to catalase, yet substitutes efficiently in peroxidations.

    4. A new oxo-vanadium radical: A cycle of peroxo-vanadium compounds is constructed to explain oxygen consumption and oxidation of a variety of compounds such a NADH, bromide and benzoate. A radical, ú2), was identified as one of the intermediates formed by ESR spectrum that resembles that of hydroxyl radical but not modified by ethanol.

    5. Polypeptide backbone in enzyme reactivity: The peptide bond between XG in the Walker loop in F1-ATPase (GXXXXGKT) flips on nucleotide binding and thus seems produces strain on the g-phosphate bond leading to its hydrolysis. This introduced the new concept that the polypeptide backbone has role in enzyme reactivity.

    6. Transmembrane domains: Functional roles for transmembrane domains have been recognized in addition to anchoring the protein in the membrane. These short stretches of about 20 residues are conserved only for the hydrophobicity, but not sequence- selective, and have random choice of exon distribution; several domains in one exon, more than one exon for one domain and two exons sharing the triplet of a residue. Their characteristic codon sequence had been identified as having a pyrimidine inas the second letter, (X C/T X)n, which makes prediction of the domains possible from DNA sequence.

    Contact Information
    Email : trs<at>cdfd.org.in
    Phone : 27171473, 27151344 Extn.1101
    Fax     : 27155479
    Last updated on : Monday, 31st January, 2005.

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